This medicine is an antidepressant used to treat depression. It may also be used to treat other conditions as determined by your doctor.
Follow the directions for taking this medicine provided by your doctor. This medicine has a MEDICATION GUIDE approved by the U.S. Food and Drug Administration. Read it carefully. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. TAKE THIS MEDICINE by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. SWALLOW THIS MEDICINE WHOLE. Do not break, crush, divide, or chew before swallowing. STORE THIS MEDICINE at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tight, light-resistant container away from heat, moisture, and light. Do not store in the bathroom. KEEP THIS MEDICINE out of the reach of children and away from pets. SEVERAL WEEKS MAY PASS BEFORE YOUR SYMPTOMS IMPROVE. Do not stop taking this medicine without checking with your doctor. TAKE YOUR DOSES AT THE SAME TIMES EACH DAY AT LEAST 8 HOURS APART unless directed otherwise by your doctor. This may help to decrease the risk of seizures with this medicine. CONTINUE TO TAKE THIS MEDICINE EVEN IF YOU FEEL WELL. Do not miss any doses. IF YOU MISS A DOSE OF THIS MEDICINE, skip the missed dose. Go back to your regular dosing schedule. Do not take more than 1 dose within 8 hours. Do not take 2 doses at once.
WARNING: Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using this medicine outweigh the risks. ALTHOUGH THIS MEDICINE IS NOT USED TO HELP PATIENTS STOP SMOKING, another brand of medicine that contains bupropion is approved for this use. Serious mental or mood problems, including depression and suicidal thoughts or actions have been reported in some patients using bupropion to help them stop smoking. FAMILY AND CAREGIVERS MUST CLOSELY WATCH patients who take this medicine. It is important to keep in close contact with the patient's doctor. Contact the doctor at once if new, worsened, or sudden symptoms such as agitation; hostility; depressed mood; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur. Discuss any questions with the patient's doctor. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are taking another medicine that contains bupropion or if you are taking or have taken linezolid or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking amantadine, antiarrhythmics (eg, propafenone, flecainide), antimalarials, (eg, mefloquine), antipsychotics (eg, haloperidol, risperidone), beta-blockers (eg, metoprolol), carbamazepine, clopidogrel, corticosteroids (eg, prednisone), cyclophosphamide, efavirenz, insulin, levodopa, lithium, lorcaserin, methylene blue, nicotine replacement therapy (eg, nicotine patches), oral hypoglycemics (eg, glipizide), orphenadrine, phenobarbital, phenothiazines (eg, thioridazine), phenytoin, pimozide, quinolone antibiotics (eg, levofloxacin), rifamycins (eg, rifampin), ritonavir, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), sympathomimetics (eg, pseudoephedrine), tamoxifen, theophylline, thiotepa, tiagabine, ticlopidine, tricyclic antidepressants (eg, nortriptyline), or other antidepressants (eg, venlafaxine). Tell your doctor if you are taking nonprescription weight loss medicines or stimulants. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including diabetes, kidney problems, liver problems (eg, cirrhosis), high blood pressure, heart problems (eg, congestive heart failure), recent heart attack, allergies, pregnancy, or breast-feeding. Tell your doctor if you have a history of a head injury or a tumor in the brain or spinal cord. Tell your doctor if you or a family member has a history of bipolar disorder (manic depression), other mental or mood problems (eg, depression), suicidal thoughts or attempts, or alcohol or substance abuse. Tell your doctor if you drink alcohol. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have a history of an eating disorder (eg, anorexia, bulimia) or seizures (eg, epilepsy). USE OF THIS MEDICINE IS NOT RECOMMENDED if you are suddenly stopping the use of alcohol, sedatives (medicines that make you sleepy), or benzodiazepines (eg, alprazolam) after long-term use. Contact your doctor or pharmacist if you have any questions or concerns about using this medicine.
SIDE EFFECTS that may occur while taking this medicine include constipation; dizziness; drowsiness; dry mouth; flushing; headache; increased sweating; increased urination; loss of appetite; nausea; nervousness; restlessness; ringing in the ears; stomach pain; taste changes; trouble sleeping; vomiting; weakness; or weight changes. If they continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience chest pain; confusion; dark urine; delusions; fainting; fast or irregular heartbeat; fever, chills, or sore throat; hallucinations; hearing problems or ringing in the ears; menstrual changes; muscle pain; new or worsening mental or mood changes (eg, concentration problems, depression, panic attacks, aggressiveness, agitation, anxiety, impulsiveness, irritability, hostility, exaggerated feeling of well-being, or inability to sit still); pale stools; red, swollen, blistered, or peeling skin; seizures; severe headache or dizziness; severe or persistent joint or muscle pain; severe or persistent nausea, vomiting, or stomach pain; severe or persistent nervousness, restlessness, or trouble sleeping; shortness of breath; suicidal thoughts or attempts; tremor; unusual swelling; vision changes; or yellowing of the skin or eyes. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; or unusual hoarseness. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
IF OVERDOSE IS SUSPECTED, contact your local poison control center or emergency room immediately. Symptoms may include chest pain; fainting; fast, slow, or irregular heartbeat; fever; hallucinations; loss of consciousness; rigid or painful muscles; seizures; severe dizziness or drowsiness; or slow or difficult breathing.
If your symptoms do not improve or if they get worse, contact your doctor. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.